Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spiny keratoderma: a common under-reported dermatosis

S L Horton1, K Hashimoto, Y Toi

  • 1Wayne State University, Detroit, Michigan, USA.

The Journal of Dermatology
|July 24, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

OCT image atlas of healthy skin on sun-exposed areas.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2018
Same author

Feature analysis of ultrasound elastography image for quantitative assessment of cutaneous carcinoma.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2017
Same author

Leiomyosarcoma of scrotum--case report and review of literature.

Urology·2006
Same author

An AIDS-associated cause of the difficult airway: supraglottic Kaposi's sarcoma.

Anesthesia and analgesia·2000
Same author

Pulsed dye laser therapy for sun damaged skin.

Lasers in surgery and medicine·1999
Same author

Selective inflammatory effect of systemic fluorouracil in actinic keratosis.

Cutis·1999
Same journal

Risk Factors for Cutaneous Immune-Related Adverse Events in the Japanese Population: A Retrospective Single-Center Cohort Study.

The Journal of dermatology·2026
Same journal

Characterization of Prurigo Nodules in Adults With Moderate-To-Severe Atopic Dermatitis in Japan: A 2-Year Observational Study.

The Journal of dermatology·2026
Same journal

Real-World Effectiveness of Tildrakizumab in Japanese Patients With Psoriasis: Analyses Stratified by Prior Systemic Therapy, Maintenance of Early Responses, and Achievement of Delayed Responses.

The Journal of dermatology·2026
Same journal

Clinical Characteristics and Treatment Patterns of Hyperhidrosis in Northern Hokkaido: A Single-Center Retrospective Descriptive Study.

The Journal of dermatology·2026
Same journal

Sparing of the Nipple-Areolar Complex and Periareolar Skin as a Diagnostic Clue for Radiation-Induced Morphea of the Breast.

The Journal of dermatology·2026
Same journal

Bullous Pemphigoid With Blister Sparing in Areas of Neurologic Impairment Caused by Syringomyelia.

The Journal of dermatology·2026
See all related articles

Spiny keratoderma, a skin condition with projections on palms and soles, is often under-reported in older adults. Manual labor and HMG-CoA reductase inhibitors may be associated factors.

Area of Science:

  • Dermatology
  • Histopathology

Background:

  • Spiny keratoderma is a rare dermatosis characterized by projections on the palms and soles.
  • Histologically, it presents a parakeratotic column above a hypogranular epidermis.

Observation:

  • Six cases were identified within a year, with patients averaging 57 years old.
  • Lesions were often unnoticed, variable in duration (4 months to 40 years), and located on palms and/or soles.
  • Associated medical history included hypertension and hyperlipidemia, often treated with HMG-CoA reductase inhibitors.

Findings:

  • The study highlights spiny keratoderma as a common, yet under-reported, condition.
  • Manual labor was a frequent characteristic among affected individuals.
  • A potential association with HMG-CoA reductase inhibitor use was noted.

Related Experiment Videos

Implications:

  • Increased awareness of spiny keratoderma is needed, particularly among older individuals and those in manual labor.
  • Further research should investigate the link between HMG-CoA reductase inhibitors and spiny keratoderma development.
  • Recognizing this condition aids in accurate diagnosis and management of palmoplantar dermatoses.