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Local cytokine expression in steroid-modified tinea faciei
1Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Japan.
The Journal of Dermatology
|July 24, 1998
Summary
This study reveals that in late-stage tinea faciei, a fungal facial infection, high levels of interferon-gamma (IFN-gamma) and macrophage migration inhibitory factor (MIF) are present, suggesting their role in delayed-type hypersensitivity.
Area of Science:
- Dermatology
- Immunology
- Mycology
Background:
- Tinea faciei is a fungal infection of the face often misdiagnosed as dermatitis.
- Steroid use can worsen tinea faciei by hindering healing and promoting fungal invasion into hair follicles.
Purpose of the Study:
- To investigate the local immune response, specifically cytokine profiles from T lymphocytes, in late-stage tinea faciei.
Main Methods:
- Analysis of cytokines from lesional T lymphocytes in late-stage tinea faciei.
- Use of RT-PCR on cryosections to detect cytokine expression.
Main Results:
- High expression of interferon-gamma (IFN-gamma) and macrophage migration inhibitory factor (MIF) was observed.
- Interleukin-4 (IL-4) and interleukin-5 (IL-5) were not detected.
Conclusions:
- IFN-gamma and MIF are likely key players in the delayed-type hypersensitivity response to fungal infections in hair follicles during late-stage tinea faciei.