Coexistence of generalized morphea with hisotological changes in lichen sclerosus et atrophicus and lichen planus

Area of Science:

• Dermatology
• Pathology
• Autoimmune Diseases

Background:

• Morphea, lichen planus, and lichen sclerosus et atrophicus (LSA) are distinct dermatological conditions.
• The etiology of these conditions is not fully understood.
• Co-occurrence of these conditions in a single patient is rare.

Observation:

• A 44-year-old Japanese woman presented with generalized sclerotic plaques consistent with morphea.
• The patient also had an oral erosive lesion histologically diagnosed as lichen planus.
• A sclerotic lesion on her thigh showed histological features of LSA.

Findings:

• Histological examination confirmed morphea, lichen planus, and LSA in the same patient.
• The co-occurrence suggests potential shared or related underlying etiologic factors.
• This case challenges the traditional classification of these conditions as entirely separate entities.

Implications:

• The findings may indicate a common pathogenic pathway or trigger for morphea, lichen planus, and LSA.
• Further research into shared etiologies could lead to novel diagnostic or therapeutic strategies.
• This case highlights the importance of considering differential diagnoses in complex dermatological presentations.