Invasive group A streptococcal disease in metropolitan Atlanta: a population-based assessment

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Published on: November 16, 2016

C A Zurawski1, M Bardsley, B Beall

  • 1Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|July 24, 1998
PubMed

Insights

Invasive group A streptococcal (GAS) disease surveillance identified high incidence in Black individuals and the elderly. Streptococcal toxic shock syndrome and M-type 1 infections increased mortality risk.

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Microbiology

Background:

  • Active, population-based surveillance for invasive group A streptococcal (GAS) disease was conducted.
  • Clinical and laboratory records were reviewed, and isolates were characterized.

Purpose of the Study:

  • To identify the incidence and risk factors of invasive GAS disease in metropolitan Atlanta.
  • To characterize the clinical features and outcomes of invasive GAS disease.

Main Methods:

  • Population-based surveillance in Atlanta laboratories from January 1994 to June 1995.
  • Review of clinical and laboratory records, and characterization of GAS isolates.

Main Results:

  • 183 cases of invasive GAS disease identified (annual incidence 5.2/100,000).
  • Highest incidence in Black individuals (9.7/100,000) and elderly (RR 13.66), especially nursing home residents.
  • Mortality was 14.4%, with higher risk for streptococcal toxic shock syndrome (STSS) and M-type 1 infections.
  • GAS disease associated with varicella in children (RR 12.19).
  • Common M types: M1 (16%), M12 (12%), M3 (11%).

Conclusions:

  • Continued study of GAS disease is essential to define risk factors and develop prevention strategies.
  • Invasive GAS disease disproportionately affects certain populations and has significant mortality risks.

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