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Published on: March 30, 2018
[Intravascular malignant B-cell lymphomatosis with renal glomerular involvement: a case]
C Charasse1, R Boulahrouz, S Le Moal
1Service de néphrologie, CHG, La Beauchée, St-Brieuc.
Nephrologie
|July 24, 1998
Summary
Intravascular malignant lymphomatosis, a rare B-cell lymphoma, can infiltrate the kidneys, causing proteinuria. This case highlights a rare glomerular localization of this lymphoma, presenting with nephrotic syndrome.
Area of Science:
- Nephrology
- Hematology
- Oncology
Background:
- Intravascular malignant lymphomatosis (IML) is a rare B-cell lymphoma predominantly affecting the central nervous system and skin.
- Neoplastic cells in IML exhibit selective homing to endothelial cells.
- Renal involvement in IML is known, but glomerular localization with proteinuria is uncommon.
Observation:
- A case of IML was observed in a 71-year-old male.
- The patient presented with proteinuria due to specific intraglomerular localization of the lymphoma.
- The nephrotic syndrome, when present in IML, is associated with minimal change disease.
Findings:
- This report details a rare instance of IML with glomerular infiltration.
- Proteinuria was a key characteristic, linked to the lymphoma's intraglomerular presence.
- The study underscores the unusual renal manifestation of IML.
Implications:
- Understanding the mechanisms of lymphocyte-endothelium adhesion molecules may elucidate IML's homing behavior.
- This case expands the known spectrum of IML presentations.
- Further research into the pathogenesis of renal IML is warranted.
