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On the resolution of fenfluramine
A T Morehead1, R A Reges, A H Lewin
1Chemistry and Life Sciences Unit, Research Triangle Institute, North Carolina 27709-2194, USA.
Enantiomer
|January 1, 1996
Abstract:
Resolution of fenfluramine with (+)-dibenzoyltartaric acid affords (+)-fenfluramine in contradiction of literature claims that (-)-fenfluramine is obtained by use of (+)-dibenzoyltartaric acid. The intermediate dibenzoyltartrate salt has been fully characterized and the absolute configuration of the enantiomers of fenfluramine has been confirmed to be as previously established. Use of (-)-dibenzoyltartaric acid, followed by use of (+)-dibenzoyltartaric acid is the preferred method for obtaining both fenfluramine enantiomers.