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[Theophylline--past present and future]
1Karl-Hansen-Klinik, Bad Lippspringe.
Arzneimittel-Forschung
|July 24, 1998
Summary
Theophylline, discovered in 1888, evolved from a diuretic to a key asthma medication. Its bronchodilator, mucociliary clearance, and diaphragmatic effects, along with optimized serum concentrations, highlight its therapeutic value.
Area of Science:
- Pharmacology
- Respiratory Medicine
Context:
- Theophylline (CAS 58-55-9) was discovered in 1888 and initially used as a diuretic.
- Its bronchodilator effects were noted in 1992 but not widely adopted until the 1970s.
- Advances in understanding its pharmacokinetics and metabolism led to sustained-release preparations.
Purpose:
- To review the historical development and therapeutic applications of theophylline.
- To highlight theophylline's multifaceted effects in managing asthma.
- To discuss its potential role in current asthma treatment guidelines.
Summary:
- Theophylline exhibits smooth bronchial muscle relaxation, increased mucociliar clearance, and improved diaphragmatic contraction.
- A defined dose-effect relationship allows for optimized theophylline serum concentrations.
- Its dual action as a symptom reliever and disease controller is recognized in asthma management.
Impact:
- Theophylline's efficacy in asthma treatment is supported by its pharmacological actions.
- Optimized dosing strategies have enhanced its therapeutic utility.
- Ongoing discussions consider theophylline's inclusion as a foundational therapy for asthma.