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Related Experiment Videos

The striatum and self-paced movements

P D Nixon1, R E Passingham

  • 1Department of Experimental Psychology, University of Oxford, United Kingdom. philip.nixon@psy.ox.ac.uk

Behavioral Neuroscience
|July 24, 1998
PubMed
Summary

Bilateral putamen lesions in monkeys impaired learned arm movements but not visually cued tasks. This suggests the putamen is crucial for recalling movements without external cues.

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Area of Science:

  • Neuroscience
  • Motor Control
  • Primate Studies

Background:

  • The putamen, a key component of the basal ganglia, plays a role in motor control.
  • Understanding the specific functions of the putamen in learned, self-initiated movements is essential for deciphering motor circuitry.

Purpose of the Study:

  • To investigate the role of the putamen in the execution of learned, self-initiated arm movements in primates.
  • To differentiate the putamen's contribution to self-initiated movements versus externally cued movements.

Main Methods:

  • Macaca fascicularis monkeys were trained on learned, self-initiated arm movement tasks.
  • Performance was assessed before and after bilateral putamen lesions.
  • A visually cued control task was used to assess motor control and motivation.

Main Results:

  • Monkeys with putamen lesions showed a significant reduction in the rate of learned, self-initiated arm movements.
  • Performance on the visually cued control task remained normal post-lesion.
  • The findings suggest the impairment is not due to motor deficits or reduced motivation.

Conclusions:

  • The putamen is critical for the recall of learned movements, particularly in the absence of external sensory cues.
  • These results align with findings from supplementary motor cortex (SMA) lesions, highlighting a cortico-striatal-thalamocortical loop.
  • The putamen's role extends beyond motor execution to include the internal generation and retrieval of learned motor sequences.

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