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Chemical constituents from Cassytha filiformis II
F R Chang1, Y C Chao, C M Teng
1Graduate Institute of Natural Products, Kaohsiung Medical College, Kaohsiung 807, Taiwan, Republic of China.
Journal of Natural Products
|July 25, 1998
Summary
Researchers isolated new compounds from Cassytha filiformis, with several known alkaloids showing significant antiplatelet aggregation activity. This discovery highlights the plant's potential in developing new antiplatelet agents.
Area of Science:
- Natural Product Chemistry
- Pharmacology
Background:
- Cassytha filiformis is a traditional medicinal herb with a history of use in various remedies.
- Alkaloids and lignans are classes of natural compounds known for diverse biological activities.
Purpose of the Study:
- To isolate and characterize new and known chemical constituents from Cassytha filiformis.
- To evaluate the antiplatelet aggregation activity of the isolated compounds.
Main Methods:
- Bioassay-directed fractionation of the methanol extract of fresh Cassytha filiformis herbs.
- Isolation and structural elucidation of compounds using spectroscopic methods.
- In vitro assessment of antiplatelet aggregation activity.
Main Results:
- Three new compounds were identified: cassyformine (aporphine alkaloid), filiformine (oxoaporphine alkaloid), and (+)-diasyringaresinol (lignan).
- Fourteen known compounds were also isolated and characterized.
- Several known compounds, including cathafiline, cathaformine, actinodaphnine, N-methylactinodaphnine, predicentrine, and ocoteine, demonstrated significant antiplatelet aggregation activity.
Conclusions:
- Cassytha filiformis is a rich source of diverse chemical entities, including novel alkaloids and lignans.
- Specific known alkaloids from Cassytha filiformis possess potent antiplatelet aggregation properties.
- These findings suggest the potential of Cassytha filiformis constituents as lead compounds for antiplatelet drug development.