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Pharmacokinetics of ifosfamide and some metabolites in children
G P Kaijser1, J De Kraker, A Bult
1Department of Pharmaceutical Analysis, Faculty of Pharmacy, Utrecht University, The Netherlands.
Anticancer Research
|July 25, 1998
Abstract:
The pharmacokinetics of ifosfamide and some metabolites in children was investigated. The patients received various doses of ifosfamide, mostly by continuous infusion, over several days. The penetration of ifosfamide and its metabolites into the cerebrospinal fluid was also studied in four cases. Ifosfamide and 4-hydroxyifosfamide pass the blood-brain barrier, reaching cerebrospinal fluid concentrations that are almost as high as plasma concentrations.