[Association analysis of polymorphism in angiotensin-converting enzyme gene in ischemic stroke]

Family and twins study demonstrated that genetic factors may be involved in stroke. Previously, insertion/deletion (I/D) Alu-polymorphism in the angiotensin-converting enzyme (ACE) gene has been suggested as a risk factor for some cardiovascular diseases. There fore, cardiovascular factors are well-known risk factors for ischemic stroke. We selected patients with ischemic stroke and with no evidence for arterial hypertension and carried out ACE polymorphism analysis. Association study of I/D polymorphism in group of these patients (52 individuals) and 80 control persons from the same population of Russian descent demonstrated no evidence for statistically significant differences in frequencies of I/D alleles or II/DD/ID genotypes between these groups. Thus, it suggests that ACE I/D polymorphism alone is not risk factor for stroke in non-hypertension patients. We cannot, however, exclude possible interaction between ACE-D/D genotype and sex.