Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human longevity determinant genes

H Rothschild1, S M Jazwinski

  • 1Section of Genetics and Geriatrics, Louisiana State University Medical Center, New Orleans, USA.

The Journal of the Louisiana State Medical Society : Official Organ of the Louisiana State Medical Society
|July 25, 1998
PubMed
Summary

Genes significantly influence longevity, as demonstrated by studies in fruit flies and nematodes. Research in mammals is advancing, linking immune function to lifespan, suggesting a genetic basis for aging.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitochondria to nucleus signaling and the role of ceramide in its integration into the suite of cell quality control processes during aging.

Ageing research reviews·2015
Same author

Correlates of functional capacity among centenarians.

Journal of applied gerontology : the official journal of the Southern Gerontological Society·2014
Same author

Age group differences in positive and negative affect among oldest-old adults: findings from the Georgia Centenarian Study.

International journal of aging & human development·2014
Same author

Life events and personality predicting loneliness among centenarians: findings from the Georgia Centenarian Study.

The Journal of psychology·2012
Same author

Multidimensional predictors of fatigue among octogenarians and centenarians.

Gerontology·2011
Same author

Cognitive performance in centenarians and the oldest old: norms from the Georgia Centenarian Study.

Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition·2010

Area of Science:

  • Molecular biology
  • Genetics
  • Gerontology

Background:

  • Recent molecular biology research highlights the role of genes in determining longevity.
  • Studies in lower organisms provide strong evidence for genetic influence on aging processes.

Purpose of the Study:

  • To summarize the genetic basis of longevity in lower organisms.
  • To discuss the emerging understanding of genetics in mammalian aging.

Main Methods:

  • Utilized selection systems in Drosophila (fruit flies) to establish the polygenic nature of longevity.
  • Analyzed gene mutations in nematodes (roundworms) to demonstrate their impact on lifespan.
  • Reviewed studies on mice relating immune function to longevity.

Main Results:

  • Longevity is a polygenic characteristic in Drosophila.
  • Individual gene mutations can modulate lifespan in nematodes.
  • Mammalian aging research is progressing, with initial findings linking immune function to longevity.

Conclusions:

  • Genes are key determinants of longevity across different organisms.
  • Genetic factors play a crucial role in the aging process.
  • Future research in mammals is expected to further elucidate the genetic underpinnings of lifespan.

Related Experiment Videos