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[Treatment of neurovegetative menopausal symptoms with a phytotherapeutic agent]
V De Leo1, D Lanzetta, R Cazzavacca
1Istituto di Ginecologia e Ostetricia, Università degli Studi-Siena.
Background:
Menopausal symptoms include hot flushes, insomnia, nocturnal sweating, dizziness, headaches and palpitations. These symptoms reflect adaptation of the body to estrogen deprivation which affects various central neurotransmitters.
Methods:
In this study, the efficacy has been tested of a plant product based on extracts of the leaves of Salvia officinalis (sage) and Medicago sativa (alfalfa) in the treatment of hot flushes in 30 menopausal women with these symptoms.
Results:
Hot flushes and night sweating completely disappeared in 20 women: four women showed good improvement and the other six showed a reduction in symptoms. GnRH and TRH tests were performed in 8 women to evaluate TSH and Prl responses before and after 3 months of therapy. The plants product induced a significant increase in Prl and TSH response to TRH. Basal levels of estradiol, LH, FSH, Prl and TSH were unchanged.
Conclusions:
The product seams to have a central slight antidopaminergic action without side effects and is an effective agent in the treatment of menopausal symptoms.