Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Macrophage activation results in bone resorption

J Lassus1, J Salo, W A Jiranek

  • 1Department of Orthopaedics and Traumatology, Helsinki University Central Hospital, Finland.

Clinical Orthopaedics and Related Research
|July 25, 1998
PubMed
Summary

Macrophages play a key role in bone remodeling and destruction. Their activation in chronic inflammation can lead to bone loss and pain, potentially causing aseptic loosening of joint implants.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lower limb clinical osteoarthritis and its association with joint pain and function, and severe injuries and surgeries, in women professional football players: a cross-sectional observational study.

South African journal of sports medicine·2025
Same author

The effect of hydroxychloroquine on activities of daily living and hand function in systemic sclerosis: results from an analysis of the EUSTAR cohort.

Arthritis research & therapy·2025
Same author

Bidirectional associations between IgE-mediated food allergy and atopic dermatitis.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2024
Same author

Preventive effects of early immunosuppressive treatment on the development of interstitial lung disease in systemic sclerosis.

Rheumatology (Oxford, England)·2024
Same author

Retention rates of different Janus kinase inhibitors in rheumatoid arthritis: experience from a large monocentric cohort.

Scandinavian journal of rheumatology·2024
Same author

Clinical significance of the anti-Nucleolar Organizer Region 90 antibodies (NOR90) in systemic sclerosis: Analysis of the European Scleroderma Trials and Research (EUSTAR) cohort and a systematic literature review.

European journal of internal medicine·2024

Area of Science:

  • Immunology
  • Orthopedics
  • Cell Biology

Background:

  • Monocytes and macrophages are crucial accessory cells regulating bone metabolism and destruction.
  • These cells are precursors to osteoclasts, and their products influence osteoblast and osteoclast activity.
  • Macrophages also process bone surfaces after osteoclast resorption, facilitating new bone formation.

Purpose of the Study:

  • To elucidate the role of macrophages in bone metabolism and destruction.
  • To explore the mechanisms by which macrophage activation contributes to bone pathologies.
  • To investigate the link between macrophage activation and aseptic loosening of orthopedic implants.

Main Methods:

  • Review of existing literature on monocyte/macrophage function in bone remodeling.

Related Experiment Videos

  • Analysis of the molecular and cellular interactions between macrophages, osteoblasts, and osteoclasts.
  • Examination of the pathological processes in chronic inflammation and foreign body reactions.

    • Main Results:

    • Activated macrophages secrete soluble products that regulate bone cell proliferation, differentiation, and activity.
    • In chronic inflammation, macrophage activation can lead to local bone demineralization and pain.
    • Macrophages degrade demineralized bone matrix, creating conditions that secondarily activate osteoclasts.
    • This process is implicated in aseptic loosening of orthopedic implants due to foreign body reactions.

    Conclusions:

    • Macrophages are central players in both normal bone remodeling and pathological bone destruction.
    • Macrophage-driven processes, particularly in chronic inflammation, can disrupt the bone remodeling cycle.
    • Understanding macrophage activation is critical for addressing conditions like aseptic implant loosening.