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Hormonal postcoital contraception

A A Kubba1

  • 1Lambeth Health Care Trust, London, UK.

The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception
|June 1, 1997
PubMed
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Hormonal postcoital contraception (HPC) effectively reduces unplanned pregnancies, with the combined estrogen/progestogen method showing over 75% risk reduction. Side effects are generally mild and do not harm pregnancy outcomes if contraception fails.

Area of Science:

  • Reproductive Health
  • Pharmacology

Background:

  • Hormonal postcoital contraception (HPC) is crucial for preventing unplanned pregnancies after unprotected intercourse or contraceptive failure.
  • The Yuzpe regimen (combined estrogen/progestogen) is the most common form of HPC.

Purpose of the Study:

  • To review the efficacy, mechanisms of action, and safety of hormonal postcoital contraception.
  • To discuss alternative progestogen-only methods and antiprogestins for emergency contraception.

Main Methods:

  • Review of existing literature on hormonal postcoital contraception efficacy and side effects.
  • Analysis of data on the Yuzpe regimen and progestogen-only formulations.
  • Evaluation of antiprogestins as a promising emergency contraception option.

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Main Results:

  • Combined estrogen/progestogen HPC reduces pregnancy risk by over 75% and is effective within 72 hours.
  • Efficacy is not affected by the time interval within the 72-hour window.
  • Side effects like nausea and vomiting are common but not serious, with no adverse effects on pregnancy outcomes if failure occurs.

Conclusions:

  • Hormonal postcoital contraception is a safe and effective method for preventing unplanned pregnancies.
  • Progestogen-only methods and antiprogestins show promise for future emergency contraception development.
  • Comprehensive counseling regarding efficacy, side effects, and ongoing contraception is essential.