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Role of vasoactive mediators in primary and secondary pulmonary hypertension
G Mikhail1, A H Chester, J S Gibbs
1National Heart and Lung Institute of Imperial College, Harefield Hospital, Middlesex, United Kingdom.
The American Journal of Cardiology
|July 25, 1998
Abstract:
The role of vasoactive mediators, such as endothelin-1, nitric oxide, prostacyclin, and thromboxane, in pulmonary hypertension remains undefined. This study investigated the circulating levels and transpulmonary gradients of these vasoactive mediators in patients with primary and secondary pulmonary hypertension to define whether there is increased production or decreased clearance of these substances in the lung vasculature.