Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

IgA nephropathy complicating diabetic glomerulosclerosis

C Orfila¹, J C Lepert, A Modesto

¹UPS EA-2405, CHU Rangueil, Toulouse, France. orfila@rangueil.inserm.fr

|July 25, 1998

Summary

Diabetic nephropathy can coexist with IgA nephropathy, a kidney disease. This association suggests potential links between glomerular basement membrane issues and immune complex diseases in diabetic patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Proposal for the delineation of postoperative primary clinical target volumes in maxillary sinus and nasal cavity cancers].

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2024

Same author

Stereotactic body radiation therapy for liver metastases in oligometastatic disease.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2023

Same author

Radiation therapy of the primary tumour and/or metastases of digestive metastatic cancers.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2023

Same author

Pembrolizumab versus cetuximab concurrent with radiotherapy in patients with locally advanced squamous cell carcinoma of head and neck unfit for cisplatin (GORTEC 2015-01 PembroRad): a multicenter, randomized, phase II trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2022

Same author

[Challenges and limits of therapeutic de-escalation for papillomavirus-related oropharyngeal cancer].

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2022

Same author

Radiation therapy and antiangiogenic therapy: Opportunities and challenges.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2022

Area of Science:

Nephrology
Immunology
Endocrinology

Background:

Diabetic nephropathy is a common complication of diabetes mellitus.
IgA nephropathy is a primary glomerulonephritis characterized by IgA deposition.
The coexistence of these two conditions presents diagnostic and therapeutic challenges.

Purpose of the Study:

To investigate the incidence and characteristics of IgA nephropathy in diabetic patients.
To explore the potential pathogenetic mechanisms linking diabetes and IgA nephropathy.
To assess the clinical impact of coexisting IgA nephropathy on diabetic nephropathy progression.

Main Methods:

Retrospective study of 66 diabetic patients who underwent renal biopsies between 1979 and 1994.
Histopathological examination including light microscopy and immunofluorescence.

Related Experiment Videos

Analysis of clinical data such as proteinuria, hematuria, and renal function.

Main Results:

Ten patients (15%) presented with coexisting IgA nephropathy and diabetic nephropathy.
Histology showed thickened glomerular basement membranes, increased mesangial matrix, and nodular sclerosis in most cases.
Immunofluorescence revealed diffuse mesangial IgA deposits in all affected patients.

Conclusions:

The high incidence suggests a link beyond coincidence between IgA nephropathy and diabetic nephropathy.
Structural/functional glomerular basement membrane abnormalities in diabetes may predispose to immune complex diseases.
Coexisting IgA nephropathy alters the clinical course of diabetic nephropathy, suggesting alternative pathogenetic mechanisms.