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The thermosome: archetype of group II chaperonins
1Max-Planck-Institut für Biochemie, Martinsried, Germany.
FEBS Letters
|July 25, 1998
Abstract:
The thermosome, the chaperonin of the archaea, and its homologue from the cytosol of eukaryotes, known as TRiC or CCT, form a distinct subfamily of the chaperonins that does not depend on a co-chaperonin for protein folding activity. Recent structural data obtained by cryo- electron microscopy and X-ray crystallography provide the first insights into a novel mechanism remarkably different from that of the bacterial GroEL-GroES system.