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Related Experiment Videos

Neutrophil adhesion on phosphorylcholine-containing polyurethanes

L Y Yung1, S L Cooper

  • 1Department of Chemical Engineering, University of Delaware, Newark 19716, USA.

Biomaterials
|July 25, 1998
PubMed
Summary

Researchers developed new polyurethanes using glycerophosphorylcholine (GPC) to reduce neutrophil adhesion. These materials show potential for minimizing inflammatory responses in biomedical applications.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Surface Science

Background:

  • Polyurethanes are widely used biomaterials.
  • Reducing foreign body response is crucial for implantable devices.
  • Phosphorylcholine incorporation can improve biocompatibility.

Purpose of the Study:

  • To synthesize polyurethanes with varying phosphorylcholine content using glycerophosphorylcholine (GPC) as a chain extender.
  • To characterize the bulk and surface properties of these novel polymers.
  • To evaluate the biocompatibility of these polyurethanes by assessing neutrophil adhesion.

Main Methods:

  • Synthesis of polyurethanes with different GPC:butanediol (BD) ratios.
  • Differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) for thermal and mechanical properties.

Related Experiment Videos

  • Dynamic contact angle analysis for surface tension.
  • Neutrophil adhesion assays under shear conditions.

    • Main Results:

    • The polymer with the highest phosphorylcholine content (PU-GPC-20) exhibited the lowest glass transition temperature (Tg) and highest mechanical strength.
    • High phosphorylcholine content led to increased microphase separation via ionic aggregation and hydrogen bonding.
    • Polymers with high phosphorylcholine content minimized interfacial tension in aqueous environments.
    • Neutrophil adhesion was significantly reduced on PU-GPC-20 compared to control polyurethanes.

    Conclusions:

    • Incorporating phosphorylcholine into the polyurethane backbone via GPC enhances mechanical properties and reduces interfacial tension.
    • The PU-GPC-20 material effectively inhibited neutrophil adhesion, suggesting reduced inflammatory and foreign body responses.
    • These phosphorylcholine-containing polyurethanes show promise as biocompatible materials for medical applications.