Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Highly swelling hydrogels from ordered galactose-based polyacrylates

B D Martin1, R J Linhardt, J S Dordick

  • 1Department of Chemical and Biochemical Engineering, College of Engineering, University of Iowa, Iowa City 52242, USA.

Biomaterials
|July 25, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Geometrical characteristics of eggs from 3 poultry species.

Poultry science·2021
Same author

Expression of enzymes for 3'-phosphoadenosine-5'-phosphosulfate (PAPS) biosynthesis and their preparation for PAPS synthesis and regeneration.

Applied microbiology and biotechnology·2020
Same author

Alveolar heparan sulfate shedding impedes recovery from bleomycin-induced lung injury.

American journal of physiology. Lung cellular and molecular physiology·2020
Same author

A method for characterising human intervertebral disc glycosaminoglycan disaccharides using liquid chromatography-mass spectrometry with multiple reaction monitoring.

European cells & materials·2018
Same author

Characteristics of global organic matrix in normal and pimpled chicken eggshells.

Poultry science·2017
Same author

Characteristics of glycosaminoglycans in chicken eggshells and the influence of disaccharide composition on eggshell properties.

Poultry science·2016
Same journal

Remodeling TME via feedback-driven photothermal-ferroptosis-immune cascade.

Biomaterials·2026
Same journal

Corrigendum to "Photodynamic therapy produces enhanced efficacy of antitumor immunotherapy by simultaneously inducing intratumoral release of sorafenib" [Biomaterials 2020, 240, 119845].

Biomaterials·2026
Same journal

Mg-integrated octopus-inspired hydrogel dressing enables autonomous adhesion and wound closure for enhanced healing via sequential microenvironment regulation.

Biomaterials·2026
Same journal

Engineering miRNA-223 nanocomplexes via bioorthogonal self-assembly for precision therapy of intervertebral disc degeneration.

Biomaterials·2026
Same journal

Corrigendum to "Enhanced fluorescence imaging guided photodynamic therapy of sinoporphyrin sodium loaded graphene oxide" [Biomaterials 42 (2015) 16442].

Biomaterials·2026
Same journal

An injectable Ce-MnCo LDH nanozyme gel with cascade catalytic activity for acute radiation proctitis in rats.

Biomaterials·2026
See all related articles

Chemists created highly swelling galactose-based hydrogels using a chemoenzymatic method. This selective enzyme catalysis produced regular, strong, and stable biomaterials for various applications.

Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Enzymatic Synthesis

Background:

  • Conventional hydrogels often lack high swelling capacity and structural regularity.
  • Developing advanced hydrogels with tunable properties is crucial for biomaterial applications.

Purpose of the Study:

  • To prepare highly swelling galactose-based hydrogels using a regioselective chemoenzymatic approach.
  • To investigate the impact of enzyme catalysis on hydrogel network regularity and properties.
  • To explore the potential of these sugar-based hydrogels as biomaterials.

Main Methods:

  • Regioselective acylation of beta-O-methyl-galactopyranoside using lipase from Pseudomonas cepacia.
  • Enzymatic synthesis of a cross-linker (2,6-diacryloyl-beta-O-methyl galactopyranoside).

Related Experiment Videos

  • Polymerization of the synthesized monomer and cross-linker to form hydrogels.

    • Main Results:

    • Achieved high swelling ratios (170-1100) and tunable elastic moduli (0.005-0.088 MPa).
    • Demonstrated significantly higher swelling compared to conventional hydrogels due to regular network structures.
    • Observed fast gel swelling kinetics, reaching 75% equilibrium in 0.17 fractional time.

    Conclusions:

    • Regioselective enzyme catalysis yields highly regular and swellable hydrogel networks.
    • These galactose-based hydrogels exhibit superior properties compared to chemically synthesized ones.
    • The materials show promise as biomaterials for enzyme immobilization and controlled delivery due to their homogeneity, stability, and tunable pore sizes.