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A modulatory effect of extracellular Ca2+ on type 1alpha metabotropic glutamate receptor-mediated signalling
R Saunders1, S R Nahorski, R A Challiss
1Department of Cell Physiology and Pharmacology, University of Leicester, UK.
Neuropharmacology
|July 29, 1998
Abstract:
Increasing [Ca2+]e from 1.3 4 mM had little effect on basal phospholipase C activity in baby hamster kidney (BHK) cells stably expressing either type 1alpha metabotropic glutamate (mGlu1alpha) or M3-muscarinic (m3) receptors, but enhanced agonist-stimulated phosphoinositide hydrolysis in BHK-mGlu1alpha, but not BHK-m3 cells, demonstrating that Ca2+(e) selectively modulates phosphoinositide signalling stimulated by this receptor subtype.