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Ring opening cross-metathesis on solid support: a combinatorial library synthesis of highly functionalized
1Sepracor Inc., Marlborough, MA 01752-7231, USA.
Molecular Diversity
|January 1, 1997
Abstract:
Ruthenium catalyzed ring opening cross-metathesis of resin-bound bicyclic alkenes with terminal aryl olefins was utilized for the construction of a combinatorial library containing highly functionalized cyclopentane derivatives. The technology described herein represents a convergent method for the diastereospecific synthesis of unique cyclopentane molecular scaffolds useful for exploratory medicinal chemistry.