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Uncertainty--a chemist's view

¹U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.

Journal of AOAC International

|July 29, 1998

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Estimating analytical method uncertainty is crucial. Alternative methods like the Youden ruggedness procedure and interlaboratory trials offer more efficient and reliable uncertainty estimation than the error budget approach.

Area of Science:

Analytical Chemistry
Metrology

Background:

Characterizing analytical method performance necessitates evaluating the uncertainty surrounding reported results.
Accurate uncertainty estimation is paramount, irrespective of the methodology employed.

Purpose of the Study:

To highlight the limitations of the error budget approach for uncertainty estimation in analytical chemistry.
To present alternative, more efficient methods for determining analytical uncertainty.

Main Methods:

Critique of the "error budget" approach, identifying its potential to overlook variables, double count others, and incorporate uncontrollable "Type B" components.
Introduction of the Youden ruggedness procedure as an alternative for uncertainty estimation and optimization.
Highlighting interlaboratory method-performance trials as a comprehensive approach to assessing uncertainty.

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Main Results:

The error budget approach is prone to overlooking variables, double counting, and incorporating uncontrollable "Type B" components.
The Youden ruggedness procedure offers a more efficient method for uncertainty estimation and can simultaneously optimize methods.
Interlaboratory trials provide an all-encompassing evaluation of method performance and uncertainty.

Conclusions:

The error budget approach is suboptimal for analytical chemistry uncertainty estimation due to inherent limitations.
The Youden ruggedness procedure and interlaboratory trials are more effective and efficient alternatives for robust uncertainty assessment in analytical methods.