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Related Experiment Videos

Salivary gland involvement in hypohidrotic ectodermal dysplasia

H Nordgarden1, S Johannessen, K Storhaug

  • 1Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, Oslo, Norway. hildeno@odont.uio.no

Oral Diseases
|July 29, 1998
PubMed
Summary

X-linked hypohidrotic ectodermal dysplasia (HED) can cause significantly reduced salivary function. Routine salivary tests in HED patients are recommended to protect oral health.

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Area of Science:

  • Dentistry
  • Genetics
  • Developmental Biology

Background:

  • Ectodermal dysplasias (EDs) comprise over 100 disorders affecting ectodermal tissues.
  • X-linked hypohidrotic ED (HED) is the most prevalent form, impacting hair, teeth, and sweat glands.
  • Previous reports suggest a link between HED and diminished salivary function.

Observation:

  • A 38-year-old male with HED presented with markedly reduced salivary fluid and acidic proline-rich protein production.
  • Computed tomography revealed hypoplasia of one submandibular and both parotid glands.
  • The right submandibular gland appeared to be absent in the patient.

Findings:

  • The observed salivary gland abnormalities in the HED patient indicate a broader developmental disturbance.

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  • Reduced salivary output and altered protein composition were key findings.
  • Glandular hypoplasia and absence suggest a congenital defect in salivary gland development.

    • Implications:

    • Routine salivary function evaluation is advised for individuals with HED.
    • Early detection of reduced salivary secretion can help mitigate adverse oral health outcomes.
    • Understanding the link between HED and salivary gland development is crucial for comprehensive patient care.