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Updated: Jul 11, 2026

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles
Published on: November 1, 2012
History dependence of force production in skeletal muscle: a proposal for mechanisms
1Faculty of Kinesiology, University of Calgary, Alberta, Canada. walter@kin.ucalgary.ca
Abstract:
Force production in skeletal muscle is history-dependent. This observation has been made numerous times in the past fifty years and the idea of history-dependent properties has been accepted in the scientific community. Nevertheless, history-dependent properties are largely neglected in theoretical models of skeletal muscles, and the mechanism responsible for these properties is not known. Here, a mechanism is proposed to explain the long-lasting, isometric force depression following muscle shortening and some of the experimental evidence in support of this mechanism is presented. Some thoughts (albeit not a mechanism) are also provided on possible explanations for the long-lasting, isometric force enhancement following muscle stretching. It is hoped that the considerations made here might stimulate a renewed interest in an old but unresolved topic in muscle mechanics.
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