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Markers of 'cell senescence'

A Macieira-Coelho1

  • 1INSERM and University of Paris VI, Versailles, France.

Mechanisms of Ageing and Development
|July 29, 1998
PubMed
Summary

Cellular senescence, a state of irreversible cell cycle arrest, is often linked to organismal aging. However, research suggests senescent cells may be more relevant in pathology than in aging, questioning the term

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Area of Science:

  • Cellular Biology
  • Gerontology
  • Pathology

Background:

  • Senescent cells are defined as cells that have exited the cell cycle and are post-mitotic.
  • This definition arose from the hypothesis that senescence is linked to organismal aging.
  • Research has focused on identifying markers to detect senescent cells in vivo across different ages.

Purpose of the Study:

  • To evaluate the relationship between cellular senescence and organismal aging.
  • To investigate markers associated with post-mitotic cells and their prevalence with age.
  • To determine the relevance of senescent cells in aging versus pathological conditions.

Main Methods:

  • Review of existing literature on cellular senescence markers.
  • Analysis of markers indicating a long resting phase (reversible or irreversible).
  • Comparison of senescent cell prevalence in aging versus disease states.

Main Results:

  • Some markers suggest an increase in post-mitotic cells with aging.
  • Other markers indicate that post-mitotic cells do not increase with age and are not relevant to aging.
  • Increased numbers of these cells are observed in pathological conditions.

Conclusions:

  • The role of senescent cells in organismal aging is debated.
  • Evidence suggests senescent cells are more prevalent in pathology than in aging.
  • The term 'senescent cell' may be a misnomer and should be used operationally.

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