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Disruption in prepulse inhibition after alpha-1 adrenoceptor stimulation in rats
B S Carasso1, V P Bakshi, M A Geyer
1Department of Neurosciences, University of California at San Diego, La Jolla 92093-0804, USA.
Neuropharmacology
|July 29, 1998
Abstract:
The role of the alpha-1 adrenoceptor in prepulse inhibition (PPI) was evaluated in rats. The alpha-1 adrenergic agonist cirazoline disrupted PPI; this effect was reversed by the alpha-1 adrenergic antagonist prazosin or the atypical antipsychotic quetiapine. Alpha-1 adrenoceptors may thus be involved in the regulation of PPI and in the psychotherapeutic actions of certain antipsychotics.