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W2H: WWW interface to the GCG sequence analysis package

M Senger1, T Flores, K Glatting

  • 1DKFZ - German Cancer Research Center, Department of Molecular Biophysics, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany. m.senger@ebi.ac.uk

Bioinformatics (Oxford, England)
|July 31, 1998
PubMed
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A new Web (WWW) interface, W2H, provides access to the GCG Sequence Analysis Software Package, overcoming limitations of the X-windows interface (WPI) on common personal computers.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomic Data Analysis

Background:

  • The graphical X-windows interface (WPI) for the GCG Sequence Analysis Software Package is often inaccessible on PCs and Macintoshes due to the absence of X-servers.
  • Web browsers are widely available on these platforms, presenting an opportunity for a web-based solution.

Purpose of the Study:

  • To develop a World Wide Web (WWW) interface, termed W2H, to the GCG Sequence Analysis Software Package.
  • To replicate the functionality of the existing X-windows interface (WPI) in a more accessible format.

Main Methods:

  • Developed W2H as a WWW interface leveraging modern web technologies such as client-pull and embedded scripting languages.
  • Designed W2H for platform independence, allowing operation across various operating systems via web browsers.

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  • Implemented features including a sequence selector, search set builder, enzyme chooser, database access, file uploading, and graphical output manipulation.
  • Incorporated secure access management for GCG server and user data.
  • Developed a special 'Intranet mode' with reduced security for specific environments like workshops and intranets.
  • Utilized meta-data files for dynamic HTML document generation and application control.

    • Main Results:

    • W2H offers comprehensive functionality comparable to the WPI, enhancing accessibility to GCG analysis tools.
    • The interface supports modern web technologies and provides reasonable platform independence.
    • Advanced features for sequence analysis, data management, and graphical output visualization are integrated.
    • Secure access and an optional intranet mode enhance usability and data protection.
    • The system's behavior is dynamically controlled via meta-data, facilitating adaptability.

    Conclusions:

    • W2H successfully provides a user-friendly and accessible WWW interface to the GCG Sequence Analysis Software Package.
    • The developed interface overcomes platform limitations, enabling broader use of powerful bioinformatics tools.
    • W2H's architecture supports extensibility and dynamic configuration through meta-data.