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NMR spectroscopy in pharmacy

U Holzgrabe1, B W Diehl, I Wawer

  • 1Pharmazeutisches Institut, Universität Bonn, Germany. holzgrabe@uni-bonn.de

Journal of Pharmaceutical and Biomedical Analysis
|July 31, 1998
PubMed
Summary

Nuclear Magnetic Resonance (NMR) spectroscopy is a versatile tool for drug analysis, structural confirmation, and quantitative analysis. This review highlights NMR

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Area of Science:

  • Analytical Chemistry
  • Pharmaceutical Sciences
  • Spectroscopy

Background:

  • Nuclear Magnetic Resonance (NMR) spectroscopy is traditionally used for drug structure elucidation and confirmation.
  • Recent advancements have expanded NMR's role in quantitative analysis within the pharmaceutical industry.

Purpose of the Study:

  • To review the diverse applications of NMR spectroscopy in drug analysis.
  • To cover methods relevant to pharmacopoeias, pharmaceutics, and pharmacokinetics.

Main Methods:

  • Structure elucidation and confirmation using NMR.
  • Quantitative analysis for impurity profiling and drug composition.
  • Solid-state NMR for polymorphism and drug conformation.
  • Micro-imaging and whole-body imaging for drug dissolution and diagnostics.

Main Results:

  • NMR spectroscopy is effective for determining drug impurity profiles.
  • Solid-state NMR provides insights into drug polymorphism and tablet conformation.
  • NMR imaging aids in studying tablet dissolution and clinical diagnostics.

Conclusions:

  • NMR spectroscopy offers a comprehensive approach to drug analysis, from structure to in vivo applications.
  • The review consolidates various NMR techniques applicable to pharmaceutical research and quality control.

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