Abnormal transoesophageal Doppler coronary flow reserve in patients with dilated cardiomyopathy: relationship to

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Z Chati1, J F Bruntz, G Ethévenot

  • 1Department of Cardiology, Hôpital Jeanne d'Arc, Nancy, France.

Clinical Science (London, England : 1979)
|July 31, 1998
PubMed

Insights

Abnormal myocardial blood flow is common in dilated cardiomyopathy but does not limit exercise capacity. This study found reduced coronary flow reserve in patients, yet it did not correlate with their exercise limitations.

Area of Science:

  • Cardiology
  • Cardiovascular Physiology

Background:

  • Dilated cardiomyopathy is associated with impaired myocardial function.
  • Abnormal myocardial blood flow is a potential contributor to reduced cardiac function.

Purpose of the Study:

  • To investigate if abnormal myocardial blood flow contributes to exercise capacity limitations in dilated cardiomyopathy patients.
  • To assess coronary flow reserve in dilated cardiomyopathy and its relation to exercise capacity.

Main Methods:

  • Assessed coronary flow reserve using transesophageal Doppler echocardiography in 16 dilated cardiomyopathy patients and 9 controls.
  • Measured peak systolic and diastolic coronary flow velocities at rest and after dipyridamole infusion.
  • Calculated coronary flow reserve as the ratio of hyperemic to basal flow velocities.

Main Results:

  • Patients with dilated cardiomyopathy had significantly lower coronary flow reserve compared to controls (P < 0.001).
  • Baseline coronary flow velocities were higher in patients.
  • Coronary flow reserve did not correlate with peak VO2 or exercise time in patients.

Conclusions:

  • Confirms previously observed abnormalities in coronary flow reserve in dilated cardiomyopathy.
  • Suggests that abnormal coronary flow reserve does not limit exercise capacity in these patients.

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