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[The effect of zinc metallothionein on lipid peroxidation in rodent bone marrow cells]
A N Koterov1, Z A Trebenok, N B Pushkareva
1State Research Center of Russia, Institute of Biophysics, Moscow.
Radiatsionnaia Biologiia, Radioecologiia
|July 31, 1998
Abstract:
It was shown, that rat hepatic Zn-metallothionein (Zn-MT) depressed in vitro Fe3+/ADP-induced lipid peroxidation (LP) in rat bone marrow cells and increased its viability after pro-oxidant's influences. ZnCl2 and its combination with cysteine also decreased LP products level, but less and did not alter viability. On 9-th day after gamma-irradiation (6 Gy) in mice protected with Zn-MT the LP products level in bone marrow was decreased in considerable extent.