Essential arginyl residues in thymidylate synthetase

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.

Biochemistry·2001

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

The Journal of biological chemistry·2001

Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Biochemistry·2000

Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

Biochemistry·2000

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Biochemistry·2000

Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.

Archives of biochemistry and biophysics·1999

Astaxanthin attenuates skeletal muscle atrophy and mitochondrial dysfunction in streptozotocin-induced diabetic rats.

Biochemical and biophysical research communications·2026

FGF13 exerts neuroprotective effects via activation of the PI3K/AKT signaling pathway and serves as a potential biomarker for depression.

Biochemical and biophysical research communications·2026

Structure and functional analysis of two insulin superfamily members in the Pacific white shrimp Litopenaeus vannamei.

Biochemical and biophysical research communications·2026

Integrated transcriptomic and functional analyses identify PRR7 as a therapeutic target that associated with Wnt/β-catenin signaling and docetaxel resistance in prostate cancer.

Biochemical and biophysical research communications·2026

Pharmacological blockade of oncogenic MAPK activators drives resistance to cystine deprivation with lipid redox remodeling.

Biochemical and biophysical research communications·2026

Helicobacter pylori small RNA HPnc1470 represses HP0499/PldA/CGAT expression and modulates gastric epithelial morphology and inflammation.

Biochemical and biophysical research communications·2026

ConfRetro: A 3D-aware Template-free Method for Enhancing Retrosynthesis via Molecular Conformer Information.

Bioinformatics (Oxford, England)·2026

Nitro Reduction-Based RNA Control and Ultrafast Release.

Angewandte Chemie (International ed. in English)·2026

Electrocatalytic nitrate reduction to ammonia: bimetallic-site catalysts, mechanistic insights, and performance optimization.

Chemical communications (Cambridge, England)·2026

Chronic Nitrogen Deposition Alters Diazotrophic Community Composition, Reduces Biological Nitrogen Fixation, and Restructures Fungal-Diazotroph CO-Occurrence Networks in Deadwood.

Microbial ecology·2026

Modulating active sites and reaction pathways: recent progress in photocatalyst design for urea synthesis.

Nanoscale·2026

Yeast Gcn2 retains activity following humanization of its auto-phosphorylation region.

FEBS open bio·2026

Related Experiment Videos

Essential arginyl residues in thymidylate synthetase

Related Concept Videos

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.

Astaxanthin attenuates skeletal muscle atrophy and mitochondrial dysfunction in streptozotocin-induced diabetic rats.

FGF13 exerts neuroprotective effects via activation of the PI3K/AKT signaling pathway and serves as a potential biomarker for depression.

Structure and functional analysis of two insulin superfamily members in the Pacific white shrimp Litopenaeus vannamei.

Integrated transcriptomic and functional analyses identify PRR7 as a therapeutic target that associated with Wnt/β-catenin signaling and docetaxel resistance in prostate cancer.

Pharmacological blockade of oncogenic MAPK activators drives resistance to cystine deprivation with lipid redox remodeling.

Helicobacter pylori small RNA HPnc1470 represses HP0499/PldA/CGAT expression and modulates gastric epithelial morphology and inflammation.

ConfRetro: A 3D-aware Template-free Method for Enhancing Retrosynthesis via Molecular Conformer Information.

Nitro Reduction-Based RNA Control and Ultrafast Release.

Electrocatalytic nitrate reduction to ammonia: bimetallic-site catalysts, mechanistic insights, and performance optimization.

Chronic Nitrogen Deposition Alters Diazotrophic Community Composition, Reduces Biological Nitrogen Fixation, and Restructures Fungal-Diazotroph CO-Occurrence Networks in Deadwood.

Modulating active sites and reaction pathways: recent progress in photocatalyst design for urea synthesis.

Yeast Gcn2 retains activity following humanization of its auto-phosphorylation region.

Related Experiment Videos

Essential arginyl residues in thymidylate synthetase

Related Concept Videos

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