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Anterior uveitis associated with latanoprost
R D Fechtner1, A S Khouri, T J Zimmerman
1Department of Ophthalmology, University of Medicine and Dentistry of New Jersey, Newark 07103, USA. fechtner@umdnj.edu
American Journal of Ophthalmology
|July 31, 1998
Summary
Latanoprost use may be associated with anterior uveitis, an eye inflammation. This inflammation improved when latanoprost was stopped and returned when it was restarted, suggesting a link.
Area of Science:
- Ophthalmology
- Clinical Pharmacology
Background:
- Glaucoma treatment often involves prostaglandin analogs like latanoprost.
- Anterior uveitis is a potential ocular side effect that requires careful monitoring.
Observation:
- Four patients with complicated open-angle glaucoma developed anterior uveitis during latanoprost therapy.
- Uveitis occurred unilaterally in three patients (affected eye received latanoprost) and bilaterally in one patient (both eyes received latanoprost).
- A history of prior ocular inflammation or surgery was present in four of the five affected eyes.
Findings:
- Discontinuation of latanoprost led to uveitis improvement, with or without corticosteroid treatment.
- Reintroduction of latanoprost in all patients resulted in recurrent uveitis, confirming a strong association.
Implications:
- A potential causal link exists between latanoprost and anterior uveitis.
- Topical prostaglandin analogs may warrant caution in patients with a history of uveitis or ocular surgery.
- The association might extend to eyes without prior uveitis or surgery.