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Peripheral retinal neovascularization (Eales disease) associated with the factor V Leiden mutation
A W Eller1, F A Bontempo, H Faruki
1Department of Ophthalmology, University of Pittsburgh School of Medicine, The Eye and Ear Institute, PA 15213, USA. aeller@vision.eei.upmc.edu
American Journal of Ophthalmology
|July 31, 1998
Summary
Eales disease, a cause of retinal neovascularization, may be linked to factor V Leiden mutation, a clotting disorder. Testing for this mutation is recommended for patients with Eales disease and a history of thrombosis.
Area of Science:
- Ophthalmology
- Hematology
- Genetics
Background:
- Eales disease is characterized by peripheral retinal neovascularization.
- Coagulopathies can contribute to thrombotic events, including those affecting the eye.
Observation:
- A 42-year-old woman presented with blurred vision and vitreous hemorrhage.
- Ophthalmoscopy revealed peripheral retinal neovascularization and temporal retinal ischemia.
- The patient had a history of cerebrovascular accident and tested positive for factor V Leiden mutation.
Findings:
- Peripheral scatter laser photocoagulation successfully regressed the retinal neovascularization.
- Warfarin sodium was initiated to prevent recurrent thrombotic events.
Implications:
- Factor V Leiden mutation testing should be considered in patients diagnosed with Eales disease.
- This is particularly important for individuals with a history of thrombotic events.
- Identifying genetic predispositions can guide management and prevention strategies for retinal vascular disorders.