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Testing for mutations of the ataxia telangiectasia gene in radiosensitive breast cancer patients
1Queensland Radium Institute Laboratory and Queensland Institute of Medical Research, Herston, Brisbane, Australia.
Background And Purpose:
To determine if clinical radiosensitivity in breast cancer patients is related to mutations of the ataxia telangiectasia gene (ATM).
Materials And Methods:
Fifteen patients who had developed a severe late reaction to a standard radiotherapy schedule were examined for evidence of increased in vitro radiosensitivity using the MTT assay. Mutation analysis was performed using a protein truncation assay.
Results:
No mutations were detected in the 15 patients despite evidence of increased in vitro radiosensitivity.
Conclusions:
Testing for the ATM gene is unlikely to be useful for predicting clinical response to radiotherapy in breast cancer patients.
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