Related Experiment Video
Updated: Aug 18, 2026

Telomerase Activity in the Various Regions of Mouse Brain: Non-Radioactive Telomerase Repeat Amplification Protocol (TRAP) Assay
Published on: September 2, 2014
Prognostic significance of telomerase in brain tumors
1Department of Neuroscience, University of Turin, Via Cherasco, 15, I-10126 Turin, Italy
Abstract:
Telomeres help to maintain chromosomal stability and integrity. They are progressively lost, conditioning aging and mortality. Telomerase enzyme activation stabilizes the telomere length, permitting the proliferation of cancer cells. Four papers are reviewed dealing with increased expression of telomerase associated with increased labelling index of MIB-1 (Ki-67) and malignancy in astrocytomas, ependymomas, and oligodendrogliomas. Telomerase expression can be utilized for differentiating malignant from benign tumors with histological resemblance. The significance of telomerase in tumor progression is discussed within the field of brain neoplasias.
Related Concept Videos
Telomeres and Telomerase
Replicative Cell Senescence
mTOR Signaling and Cancer Progression
The mTOR pathway or the...

