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Role of PTHrP and PTH-1 receptor in endochondral bone development
1Division of Endocrinology, Department of Medicine, and Lady Davis Institute for Medical Research, McGill University, Montreal, Canada. akarapli@ldi.jgh.mcgill.ca
Abstract:
Parathyroid hormone-related peptide (PTHrP) has important functions in the control of cellular growth and differentiation. Acting, at least in part, through the PTH-1 receptor, PTHrP profoundly influences chondrocytic and osteogenic cell biology. Studies using knockout and transgenic mouse technology have played a pivotal role in unraveling the physiological role of PTHrP and its receptor in endochondral bone development and adult skeletal homeostasis. Further clarification of these functions will have far-reaching implications in our general understanding of skeletogenesis and the pathophysiology of human skeletal disorders.