Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Allergic immunobiology and anesthesiology]

A Sabbah1, S Hassoun, M Drouet

  • 1Laboratoire d'Immuno-Allergologie-CHU, Angers.

Allergie Et Immunologie
|July 31, 1998
PubMed
Summary

This study presents a two-stage protocol to identify the cause of anaphylactic reactions after surgery. The protocol effectively correlates mediator release with IgE-mediated responses, confirming anaphylaxis origins.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associations between foot lesions and carcass traits in young bulls reared indoors.

Animal : an international journal of animal bioscience·2025
Same author

Muscle regeneration after high-dose radiation exposure: therapeutic potential of Hedgehog pathway modulation?

International journal of radiation biology·2021
Same author

Gene Expression Changes in Irradiated Baboons: A Summary and Interpretation of a Decade of Findings.

Radiation research·2021
Same author

Differentiating Total- or Partial-Body Irradiation in Baboons Using mRNA Expression Patterns: A Proof of Concept.

Radiation research·2020
Same author

miRNA Expression Patterns Differ by Total- or Partial-Body Radiation Exposure in Baboons.

Radiation research·2019
Same author

Gene therapy and cell therapy for the management of radiation damages to healthy tissues: Rationale and early results.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2019

Area of Science:

  • Anesthesiology
  • Immunology
  • Allergy

Background:

  • Post-operative anaphylaxis is a critical concern requiring accurate diagnosis.
  • Distinguishing between different anaphylactic pathways is essential for appropriate management.
  • Current diagnostic methods may not fully capture the complexities of post-operative allergic reactions.

Observation:

  • A novel two-stage diagnostic protocol was developed to investigate anaphylactic accidents post-surgery.
  • The protocol involves sequential measurement of anaphylaxis mediators (histamine, tryptase, methylhistamine, leukotriene E4) in the early hours post-reaction.
  • A secondary, later-stage evaluation focuses on identifying IgE-mediated mechanisms through specific IgE, basophil activation, and other tests.

Findings:

  • The protocol demonstrated a significant correlation between early mediator release and later confirmed IgE-mediated reactions.

Related Experiment Videos

  • Validation in 16 subjects confirmed the protocol's reliability in defining the origin of anaphylactic events.
  • The findings support the sequential measurement of mediators as a reliable indicator of anaphylaxis in the post-operative setting.

    • Implications:

    • This protocol offers a standardized approach to diagnosing post-operative anaphylaxis, improving patient care.
    • Accurate identification of anaphylaxis triggers can lead to better prevention strategies and treatment.
    • The study validates a comprehensive diagnostic pathway for complex allergic reactions in surgical patients.