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Endoscopic biliary manometry in cholecystectomized patients with and without choledocholithiasis
M Ugljesic1, M Bulajic, T Milosavljevic
1Institute for Digestive Diseases, University Clinical Center, Belgrade, Yugoslavia.
Hepato-Gastroenterology
|July 31, 1998
Summary
Sphincter of Oddi dysfunction, characterized by increased retrograde phasic contractions, is linked to the formation of common bile duct stones. This finding suggests abnormal sphincter of Oddi function plays a role in choledocholithiasis development.
Area of Science:
- Gastroenterology
- Biliary Physiology
Background:
- Sphincter of Oddi (SO) dysfunction is implicated in bilio-pancreatic disorders.
- Endoscopic manometry enables direct study of SO function.
Purpose of the Study:
- To investigate the relationship between SO dysfunction and the formation of common bile duct stones (choledocholithiasis).
Main Methods:
- Endoscopic biliary manometry was performed on 45 post-cholecystectomy patients and 9 healthy controls.
- Patients were categorized based on the presence or absence of common bile duct stones via endoscopic retrograde cholangiography.
Main Results:
- Patients with choledocholithiasis exhibited a significant increase in retrograde phasic contractions of the SO compared to controls (p < 0.05).
- A higher frequency of SO phasic contractions was observed in patients with choledocholithiasis versus those without stones, but not significantly different from controls.
- Markedly increased SO basal pressure was noted in some patients with choledocholithiasis and one without.
Conclusions:
- Manometric abnormalities in the SO of patients with choledocholithiasis suggest SO dysfunction is related to common bile duct stone formation.
- Pathophysiological mechanisms involving the SO may contribute to the development of choledocholithiasis.