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Percutaneous absorption of disopyramide, lidocaine and trimecaine
J Príborský1, K Kikuchi, K Takayama
1Glaxo Wellcome s.r.o., Prague, Czech Republic.
Acta Universitatis Palackianae Olomucensis Facultatis Medicae
|July 31, 1998
Abstract:
Promoting effect of cyclic monoterpenes on percutaneous absorption of antiarrythmics drugs disopyramide, lidocaine and trimecaine was investigated in the rats. Laurocapram (Azone) was used as a standard comparator of penetration enhancement. The absorption of trimecaine was significantly enhanced by addition of limonene, trans-p-menthane and Azone in 1% concentration. Lidocaine and disopyramide penetrated across the skin only when 1% of limonene was used. Other cyclic monoterpenes showed no effect on percutaneous absorption of examined drugs.