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Studies on the Plasmodium vivax relapse pattern in Delhi, India
T Adak1, V P Sharma, V S Orlov
1Malaria Research Centre (ICMR), Sham Nath Marg, Delhi, India.
The American Journal of Tropical Medicine and Hygiene
|July 31, 1998
Summary
This study investigated Plasmodium vivax malaria relapses in Delhi, finding relapse rates between 23-44%. Findings suggest distinct tropical and temperate strains of P. vivax, impacting malaria control strategies.
Area of Science:
- Epidemiology
- Infectious Diseases
- Malariology
Background:
- Plasmodium vivax causes recurrent malaria infections.
- Understanding relapse patterns is crucial for effective malaria control.
- Delhi experiences significant malaria transmission.
Purpose of the Study:
- To determine the relapse rate of Plasmodium vivax infections.
- To analyze the seasonal correlation between primary infection and relapses.
- To investigate incubation period durations and relapse patterns.
Main Methods:
- A five-year prospective epidemiologic study.
- Involved patients attending a Delhi malaria clinic.
- Data collected on infection, relapse, and follow-up duration.
Main Results:
- Relapse rates varied from 23% to 44% based on follow-up.
- Observed relapse patterns suggest co-existence of tropical and temperate P. vivax.
- Evidence for P. vivax subpopulations with distinct, long incubation periods.
Conclusions:
- The study identified significant relapse rates for P. vivax in Delhi.
- Distinct P. vivax types with varying incubation periods were inferred.
- Findings have implications for malaria epidemiology and control strategies.