Related Experiment Videos
Effect of aminoguanidine on optic nerve involvement in experimental diabetic rats
M Ino-ue1, N Ohgiya, M Yamamoto
1Department of Ophthalmology, School of Medicine, Kobe University 7-5-2, Kusunoki-Cho, Chuo-ku, Kobe 650-0017, Japan. mymam956@mailgate.kobe-u.ac.jp
Brain Research
|August 1, 1998
Abstract:
The effect of aminoguanidine (AG) on structural abnormalities in optic nerve fibers was evaluated in streptozotocin-induced diabetic rats. Morphometry of myelinated optic nerve fibers showed a partial amelioration on the reduction of the axon size but complete preservation of myelin size with low dose (25 mg kg-1 body weight) AG treatment. High dose (100 mg kg-1 body weight) AG completely prevented myelinated nerve fiber atrophy. These findings indicated that nonenzymatic glycation contributes to the development of optic nerve changes in diabetic rats.