Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mutagenesis induced by the tumor microenvironment

J Yuan1, P M Glazer

  • 1Departments of Therapeutic Radiology, Genetics, and Biology, Yale University School of Medicine, P.O. Box 208040, New Haven, CT 06520-8040, USA.

Mutation Research
|August 1, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A trend towards increasing viral load in newly diagnosed HIV-infected inpatients in southeast China.

Epidemiology and infection·2016
Same author

Clinical Study: Change in Outlook Towards Birth After a Midwife Led Antenatal Education Programme Versus Hypnoreflexogenous Self-Hypnosis Training for Childbirth.

Geburtshilfe und Frauenheilkunde·2016
Same author

Adolescent exposure to cocaine increases anxiety-like behavior and induces morphologic and neurochemical changes in the hippocampus of adult rats.

Neuroscience·2015
Same author

Induction effect of MicroRNA-449a on glioma cell proliferation and inhibition on glioma cell apoptosis by promoting PKCα.

European review for medical and pharmacological sciences·2015
Same author

Effect of Bacillus subtilis CGMCC 1.1086 on the growth performance and intestinal microbiota of broilers.

Journal of applied microbiology·2015
Same author

Complete mitochondrial genome of the Chinese Hwamei Garrulax canorus (Aves: Passeriformes): the first representative of the Leiothrichidae family with a duplicated control region.

Genetics and molecular research : GMR·2015

The tumor microenvironment, characterized by hypoxia and low pH, can directly cause mutations. This review examines how these external factors drive tumor progression and genetic instability.

Area of Science:

  • Oncology
  • Cancer Biology
  • Genetics

Background:

  • Genomic instability is a hallmark of cancer, often attributed to endogenous genetic factors.
  • The tumor microenvironment (TME) presents unique conditions like hypoxia, acidity, and nutrient deprivation.
  • Emerging evidence highlights the TME as a potential mutagenic source contributing to cancer progression.

Purpose of the Study:

  • To review the mutagenic role of the tumor microenvironment in cancer development.
  • To explore how specific microenvironmental factors induce genetic instability.
  • To re-examine the contribution of exogenous factors to tumor progression.

Main Methods:

  • Literature review of in vivo and in vitro studies.
  • Analysis of research on cellular metabolism and physiology under TME conditions.

Related Experiment Videos

  • Synthesis of evidence linking TME factors to mutagenesis.

    • Main Results:

    • Hypoxia, low pH, and nutrient deprivation disrupt cellular metabolism and physiology.
    • Exposure to adverse TME conditions directly induces mutations in tumor cells.
    • The TME is a significant contributor to overall genetic instability in solid tumors.

    Conclusions:

    • The tumor microenvironment is an active driver of mutagenesis, not just a passive bystander.
    • Understanding TME-induced mutagenesis is crucial for developing novel cancer therapies.
    • Targeting the TME could be a strategy to reduce genetic instability and tumor progression.