Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chromosome 4 workshop

J L Kennedy1, F M Macciardi

  • 1Clarke Institute of Psychiatry, University of Toronto, Ontario, Canada.

Psychiatric Genetics
|August 1, 1998
PubMed
Summary
This summary is machine-generated.

Genetic linkage studies suggest chromosome 4p may harbor susceptibility loci for bipolar disorder and schizophrenia. Further research, including dopamine D5 receptor gene analysis, is needed to confirm these findings and explore alcoholism connections.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

North Eastern Iowa Veterinary Medical Association.

The Journal of comparative medicine and veterinary archives·2022
Same author

Influence of BDNF Val66Met polymorphism on excitatory-inhibitory balance and plasticity in human motor cortex.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2021
Same author

Erratum for Kennedy et al., "Genome Sequences of Three Novel Isolates of Human Parainfluenza Virus 2 Associated with Acute Respiratory Infection".

Genome announcements·2017
Same author

Genome Sequences of Three Novel Isolates of Human Parainfluenza Virus 2 Associated with Acute Respiratory Infection.

Genome announcements·2017
Same author

Genome-wide association studies of placebo and duloxetine response in major depressive disorder.

The pharmacogenomics journal·2017
Same author

Polymorphisms of the oxytocin receptor gene and overeating: the intermediary role of endophenotypic risk factors.

Nutrition & diabetes·2017
Same journal

Dissecting causal and putative mechanistic pathways from lifestyle factors to neurological diseases via the glymphatic system: a Mendelian randomization study.

Psychiatric genetics·2026
Same journal

A rare missense variant in Bruton's tyrosine kinase is associated with bipolar disorder accompanied by psychosis.

Psychiatric genetics·2026
Same journal

Identification of rare missense variants of ionotropic glutamate receptor N-methyl-D-aspartate 2 genes in patients with schizophrenia.

Psychiatric genetics·2026
Same journal

Expression and function of miR-218-5p in the pathogenesis of postpartum depression.

Psychiatric genetics·2026
Same journal

Case report of a boy with autism spectrum disorder and lysinuric protein intolerance.

Psychiatric genetics·2026
Same journal

Familial co-occurrence of autism spectrum disorder and 47 XYY syndrome: revisiting the role of Y chromosome dosage in neurodevelopment.

Psychiatric genetics·2026
See all related articles

Area of Science:

  • Genetics
  • Neuroscience
  • Psychiatry

Background:

  • Investigating genetic factors contributing to complex psychiatric disorders like bipolar disorder and schizophrenia.
  • Examining the role of specific chromosomal regions and candidate genes in disease etiology.
  • Assessing the current state of evidence for linkage and association studies.

Framework:

  • Focus on chromosome 4, specifically regions 4p and 4q, for potential susceptibility loci.
  • Evaluate findings from multiple research groups regarding linkage and allelic association.
  • Consider the dopamine D5 receptor gene (DRD5) as a candidate gene due to its relevance in psychotic disorders.

Implementation:

  • Analyze results from linkage analyses and allelic association studies in families with bipolar disorder and schizophrenia.

Related Experiment Videos

  • Discuss the need for additional markers and haplotype analysis for genes like DRD5.
  • Acknowledge preliminary findings related to alcohol use disorder (AUD) candidate gene clusters (ADH, GABA).

    • Implications:

    • Suggests chromosome 4p as a promising region for further investigation in bipolar disorder and schizophrenia.
    • Highlights the potential utility of DRD5 and other candidate genes in understanding disease mechanisms.
    • Underscores the necessity for larger sample sizes and refined genetic studies to clarify the role of chromosome 4 in these disorders and potentially alcoholism.