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Zinc deficiency in rapidly growing preterm infants
M Obladen1, A Loui, W Kampmann
1Department of Neonatology, Charité Virchow Klinikum, Humboldt University, Berlin, Germany.
Acta Paediatrica (Oslo, Norway : 1992)
|August 1, 1998
Summary
Subclinical zinc deficiency is common in very low birthweight infants. Current infant formulas and breast milk fortifiers may not provide adequate zinc for these vulnerable infants.
Area of Science:
- Neonatal nutrition
- Trace element metabolism
Background:
- Very low birthweight (VLBW) infants have unique nutritional needs due to rapid growth.
- Subclinical deficiencies of essential nutrients like zinc (Zn) can impact VLBW infant health.
Observation:
- A case of symptomatic zinc deficiency was noted in a preterm infant exclusively fed maternal breast milk.
- Serum zinc concentrations were assessed in 26 VLBW infants before discharge.
Findings:
- 14 out of 26 VLBW infants exhibited serum zinc levels below the normal range.
- Serum zinc concentrations did not correlate with serum alkaline phosphatase or iron intake.
- Current nutritional practices in Germany, including fortified breast milk and preterm formulas, may be insufficient in zinc for VLBW infants.
Implications:
- There is a need to re-evaluate zinc content in infant formulas and breast milk fortifiers for VLBW infants.
- Optimizing zinc supply is crucial for the healthy growth and development of extremely low birthweight infants.
- Further research is warranted to establish optimal zinc requirements for VLBW neonates.