Related Experiment Videos
Efaroxan, an alpha-2 antagonist, in the treatment of progressive supranuclear palsy
O Rascol1, K Sieradzan, H Peyro-Saint-Paul
1Department of Clinical Pharmacology, University Hospital, Toulouse, France.
Abstract:
We have tested, in a prospective randomized, double-blind, placebo-controlled, crossover, 12-week study, the effects of 2 mg efaroxan, a potent alpha-2 antagonist, given three times per day to 14 patients with progressive supranuclear palsy. Efaroxan did not induce any significant change on any motor assessment criteria. The present data do not confirm the assumption that the blockade of alpha-2 receptors might be a useful pharmacologic strategy to improve patients with progressive supranuclear palsy.