Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Parkinsonism with HIV infection

S M Mirsattari1, C Power, A Nath

  • 1Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.

Movement Disorders : Official Journal of the Movement Disorder Society
|August 1, 1998
PubMed
Summary

Parkinsonism can affect individuals with human immunodeficiency virus (HIV) infection, sometimes triggered by neuroleptic medications. Treatment responses vary, suggesting HIV may directly cause these neurological symptoms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient experience after pelvic exenteration: chronic pain and quality of life.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026
Same author

Long-Range Transverse-Momentum Correlations and Radial Flow in Pb-Pb Collisions at the LHC.

Physical review letters·2026
Same author

The rate of non-sentinel lymph node metastases at axillary dissection in patients with a positive sentinel lymph node after neoadjuvant chemotherapy.

Surgical oncology·2026
Same author

Measurement of the Positive Muon Anomalous Magnetic Moment to 127 ppb.

Physical review letters·2025
Same author

Search for Quasiparticle Scattering in the Quark-Gluon Plasma with Jet Splittings in pp and Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2025
Same author

First Measurement of A=4 Hypernuclei and Antihypernuclei at the LHC.

Physical review letters·2025

Area of Science:

  • Neurology
  • Infectious Diseases
  • Neurovirology

Background:

  • Human immunodeficiency virus (HIV) infection is associated with a range of neurological complications.
  • Parkinsonism, a syndrome characterized by motor impairments, has been anecdotally linked to HIV infection.

Observation:

  • This study details 16 patients with HIV infection presenting with parkinsonism or parkinsonian features.
  • In 50% of cases, neuroleptic medication use preceded the onset of symptoms.
  • In the remaining cases, HIV infection was the only identified potential cause.

Findings:

  • Discontinuation of neuroleptics led to full recovery in one patient and partial/no recovery in others.
  • Two patients experienced rapid parkinsonism progression, with one on high-dose zidovudine (AZT) and benztropine.
  • Parkinsonism in HIV-infected individuals can be akinetic and may not always respond to treatment.

Implications:

  • Patients with acquired immunodeficiency syndrome (AIDS) are susceptible to developing neuroleptic-precipitated or idiopathic akinetic parkinsonism.
  • The variable response to treatment highlights the complexity of managing parkinsonism in this population.
  • Parkinsonism may represent an additional primary neurological syndrome directly induced by HIV infection.

Related Experiment Videos