Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Familial retinoblastoma: where and when?

D H Abramson1, M E Mendelsohn, C A Servodidio

  • 1Ophthalmic Oncology Center, New York Hospital-Cornell Medical Center, NY, USA.

Acta Ophthalmologica Scandinavica
|August 1, 1998
PubMed
Summary

For patients with a family history of retinoblastoma, new tumors typically appear within the first year of life. Tumor location, particularly in the macula, follows a predictable pattern based on age at diagnosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ocular and systemic toxicity of high-dose intravitreal topotecan in rabbits: Implications for retinoblastoma treatment.

Experimental eye research·2022
Same author

A predominant Th1 polarization is present in synovial fluid of end-stage osteoarthritic knee joints: analysis of peripheral blood, synovial fluid and synovial membrane.

Clinical and experimental immunology·2018
Same author

Breast cancer risk after radiotherapy for heritable and non-heritable retinoblastoma: a US-UK study.

British journal of cancer·2014
Same author

Intra-arterial chemotherapy as a treatment for intraocular retinoblastoma: alternatives to direct ophthalmic artery catheterization.

AJNR. American journal of neuroradiology·2012
Same author

Pilot trial of sunitinib therapy in patients with von Hippel-Lindau disease.

Annals of oncology : official journal of the European Society for Medical Oncology·2011
Same author

[Regulatory B cells and their role in maintaining peripheral tolerance].

Zeitschrift fur Rheumatologie·2010

Area of Science:

  • Ophthalmology
  • Pediatric Oncology
  • Genetics

Background:

  • Retinoblastoma is the most common primary intraocular malignancy in children.
  • A family history of retinoblastoma increases the risk of developing the disease.
  • Early detection and monitoring are crucial for favorable outcomes.

Purpose of the Study:

  • To establish the timeline for intraocular disease development in at-risk children.
  • To identify the locations where new retinoblastoma tumors typically arise.
  • To understand the pattern of tumor occurrence in relation to age and affected eye.

Main Methods:

  • Retrospective chart review of retinoblastoma patients.
  • Analysis of initial eye examination status and subsequent tumor development.

Related Experiment Videos

  • Correlation of tumor location with age at diagnosis.

    • Main Results:

    • 62% of first eyes with prior normal exams developed retinoblastoma by 6 months; 90% by 12 months.
    • 27% of second eyes were affected by 6 months; 64% by 12 months.
    • Younger age at diagnosis correlated with posterior pole tumors; macular tumors appeared early, with no new macular tumors after initial diagnosis.

    Conclusions:

    • The onset, location, and frequency of new retinoblastoma tumors exhibit a predictable pattern.
    • Age at diagnosis is a key factor in determining tumor location.
    • Macular tumors present early, and their development appears to cease after initial diagnosis.