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Active efflux of norfloxacin by Bacteroides fragilis
S Miyamae1, H Nikaido, Y Tanaka
1Department of Microbiology, School of Dentistry, Aichi-Gakuin University, Nagoya 464-8650, Japan.
Antimicrobial Agents and Chemotherapy
|August 4, 1998
Abstract:
Norfloxacin was actively pumped out by Bacteroides fragilis, which is intrinsically resistant to most fluoroquinolones. Reserpine moderately inhibited the efflux. A one-step spontaneous mutant had increased resistance to norfloxacin, ethidium bromide, and puromycin, a result suggesting that the efflux is catalyzed by a multidrug pump with specificity similar to that of NorA/Bmr.