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Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis
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[History of the techniques of obtaining skin]

V Voinchet1, G Magalon

  • 1Service de Chirurgie Plastique et Reconstructrice, Hôpital de la Conception, Marseille.

Annales De Chirurgie Plastique Et Esthetique
|October 1, 1996
PubMed

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...